Reference of 150-78-7, The chemical industry reduces the impact on the environment during synthesis 150-78-7, name is 1,4-Dimethoxybenzene, I believe this compound will play a more active role in future production and life.
EXAMPLE 61 (+,-)-N-(cis-2-(3,6-dimethoxy-2-fluorophenyl)-cyclopropyl)-N’-(5-chloropyrid-2-yl)-urea To a solution of 1,4-dimethoxybenzene (15.0 g, 0.109 mol) in 300 mL of dry THF was added 2.5M n-butyllithium (45.6 mL, 0.114 mol) at room temperature under nitrogen. After addition was complete, the solution was stirred for 1 hr. The mixture was cooled to -70 C. and N-fluorobenzenesulfonimide (36.0 g, 0.114 mol) in 150 mL of THF was added slowly, keeping the temperature below -60 C. The solution was allowed to warm to room temperature during the night. 100 mL of NH4 Cl (sat) was added and the mixture was extracted with diethyl ether/THF. The organic phase was washed with 1M NaOH (2*60 mL), dried over MgSO4 and evaporated. Column chromatography (silica gel, n-hexane followed by 1, 5 and 10% EtOAc in n-hexane) provided 11.43 g of a mixture of 1,4-dimethoxy-2-fluorobenzene and 1,4-dimethoxybenzene (4.3:1). This mixture was reacted in a manner analogous to Examples 362, 375 and 348 of WO 93/03022 to give (+,-)-cis-2-(3,6-dimethoxy2-fluorophenyl) cyclopropylamine.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dimethoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Medivir AB; US5849769; (1998); A;,
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