Alkoxy cyanoacrylate-based nanoparticles with stealth and brain-targeting properties was written by Liu, Jimin;Li, Yunfeng;Liu, Shan;Zhang, Yi;Luo, Yuan;Yang, Yang;Zhuang, Xiaomei;Wang, Xuanzhi;Zhao, Baoquan;Xu, Tao;Xu, Liang. And the article was included in Journal of Drug Targeting in 2022.Application of 111-77-3 This article mentions the following:
Nanoparticles (NPs) with 閳ョ灚tealth閳?properties have been designed to decrease the phagocytosis of such particles by mononuclear phagocytes and to protect them from enzymic degradation, thus improving circulation time and bioavailability after i.v. administration. Brain-targeting modifications endow NPs with the capacity to cross the blood-brain barrier, facilitating chemotherapy for brain diseases such as glioma. In this study, newly designed alkoxy cyanoacrylate (CA)-based NPs with stealth and brain-targeting properties were synthesized and evaluated. The monomers for NP core polymerization were chem. modified to hydrophilic short alkoxy structure for stealth purposes and coated with polysorbate-80 for brain targeting. Two monomers (2-methoxyethyl CA and 2-(2-methoxyethyl)ethyl CA) were used to create NP2 and NP3, resp. Both NPs were successfully loaded with anti-sense oligonucleotide (ASON) of transforming growth factor beta 2. Compared to traditional Bu CA-based ASON-NP1, ASON-NP3 was found to decrease phagocytosis by mononuclear macrophages (RAW264.7) and to increase cellular uptake by cancer cells. ASON-NP3 showed definite brain targeting and anti-cancer effects. This work provides a potential new strategy for preparing stealth NPs core, providing a new NP vehicle for clin. drug delivery that may be targeted to the brain and circulates in the blood for an extended period of time. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Application of 111-77-3).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 111-77-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem