Development of a scalable synthesis of SIRT1 modulator macrocycles was written by Tatai, Janos;Molnar, Mark;Villeneuve, Maud;Haberkorn, Laure;Nyerges, Miklos. And the article was included in Heterocycles in 2022.Recommanded Product: 3-Methyl-4-nitroanisole This article mentions the following:
An improved multigram route to key intermediate for macrocyclic SIRT1 modulators was developed. The increasing demand for this key intermediate caused the rerouting of the initial discovery route resulted in increase of overall yield to 8.3% over 8 steps, with the elimination of some tedious chromatog. purifications and the substitution of critical reaction steps, which hindered a feasible scale-up. The key modification was the introduction of the microwave assisted intramol. Suzuki reaction for the macrocyclization step, which provided in a reliable and reproducible manner of the targeted product. This newly developed synthetic access to this first described macrocyclic ring system was capable of ensuring the supply of our medicinal chem. program. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Recommanded Product: 3-Methyl-4-nitroanisole).
3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 3-Methyl-4-nitroanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem