Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds using iodine and bromine or their sodium salts in the presence of the Fe(NO3)3璺?.5N2O4/charcoal system was written by Firouzabadi, H.;Iranpoor, N.;Shiri, M.. And the article was included in Tetrahedron Letters in 2003.HPLC of Formula: 75581-11-2 This article mentions the following:
Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds with I and Br or their Na salts proceed well in the presence of Fe(NO3)3璺?.5N2O4/charcoal in CH2Cl2 at room temperature In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2HPLC of Formula: 75581-11-2).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.HPLC of Formula: 75581-11-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem