Controlled Self-Assembly of Carbohydrate Conjugate Rod-Coil Amphiphiles for Supramolecular Multivalent Ligands was written by Kim, Byung-Sun;Hong, Dong-Je;Bae, Jinyoung;Lee, Myongsoo. And the article was included in Journal of the American Chemical Society in 2005.HPLC of Formula: 60221-37-6 This article mentions the following:
Carbohydrate conjugate rod-coil amphiphiles were synthesized and their self-assembling behavior in aqueous solution was investigated. These amphiphiles were observed to self-assemble into supramol. structures that differ significantly depending on the mol. architecture. The rod-coil amphiphiles based on a short coil (1) self-assemble into a vesicular structure, while the amphiphiles with a long coil (2) show a spherical micellar structure. In contrast, 3, based on a twin-rod segment, was observed to aggregate into cylindrical micelles with twice the diameter of mol. length scale. As a means to determine the binding activity to protein receptors of these supramol. objects, hemagglutination inhibition assay was performed. The experiments showed that the supramol. architecture has a significant effect on the binding activity. In addition, incubation experiments with Escherichia coli showed that mannose-coated objects specifically bind to the bacterial pili of the ORN 178 strain. These results demonstrate that precise control of the nano-objects in shape and size by mol. design can provide control of the biol. activities of the supramol. materials. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6HPLC of Formula: 60221-37-6).
2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 60221-37-6
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem