Kinetics and mechanism of thermal gas-phase elimination of 2-aryloxyacetic acid was written by Al-Awadi, Nouria A.;Kumar, Ajith;Chuchani, Gabriel;Herize, Armando. And the article was included in International Journal of Chemical Kinetics in 2001.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
Rates of thermal gas-phase elimination of eleven 2-aryloxyacetic acid have been measured over a 45鎺矯 temperature range for each compound Hammett correlation of the present kinetic data with the literature 锜?sup>0 values of the given substituents gave a reaction 锜?constant of 0.69 at 600 K; this is more than that for the gas-phase elimination parameter of 2-aryloxypropanoic acid (锜?= 0.26) and consistent with a transition state with some charge separation, suggesting a partial formation of carbocation. The implications of this observation for the thermal gas-phase elimination of 浼?aryloxycarboxylic acids are considered. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem