Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41365-75-7, name is 1-Amino-3,3-diethoxypropane, A new synthetic method of this compound is introduced below., Recommanded Product: 41365-75-7
j00273J To a solution of [(R)-(4-chlorophenyl)-[(25,3 S,4R, 5R)-5-(4-chloropyrrolo[2,3 – d]pyrimidin-7-yl)-3 ,4-dihydroxy-tetrahydrofuran-2-yl]methyl] 4-phenylbenzoate (Int-3) (400 .mg,0.69 mmol) in Ethanol (2 mL), 3,3-diethoxypropan-1-amine (2.mL, 12.36 mmol) was added. The mixture was stirred at 80 C for 4 h. LCMS indicated the reaction was completed and formation of the mixture of 22a. The mixture of crude products was used directly for the next step.:_1002741 To the reaction mixture of compound 22a (both [(R)-(4-chlorophenyl)- [(2S,3 S,4R,5R)-5-[4-(3 ,3 -diethoxypropylamino)pyrrolo[2,3 -d]pyrimidin-7-yl]-3 ,4-dihydroxy- tetrahydrofuran-2-yl]methyl] 4-phenylbenzoate (4.mL, 0.16 mmol) and (2R,3 S,4R,5R)-2-[(R)-(4- chlorophenyl)-hydroxy-methyl] -5 -[4-(3 ,3 -diethoxypropylamino)pyrrolo[2, 3 -d]pyrimidin-7- yl]tetrahydrofuran-3 ,4-diol (4 .mL, 0.53 mmol) was contained), hydrazine hydrate (2. mL, 41.15 mmol) was added. The mixture was stirred at 25 C for 4 h. The mixture was purified by reverse phase Chem-flash eluting with CH3CN/H20 from 10/90 to 90/10 to give (2R,35,4R,5R)-2-[(R)-(4- chlorophenyl)-hydroxy-methyl] -5 -[4-(3 ,3 -diethoxypropylamino)pyrrolo[2, 3 -d]pyrimidin-7-yl]tetrahydrofuran-3,4-diol (22b) (297 mg, 0.557 mmol, 85.2% yield) (total yield over two steps) as a yellow solid. LCMS M+H: 507.1
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PRELUDE THERAPEUTICS, INCORPORATED; LUENGO, Juan; LEAL, Raul, A.; LIN, Hong; SHETTY, Rupa; (153 pag.)WO2018/152501; (2018); A1;,
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