In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2734-70-5, name is 2,6-Dimethoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2,6-Dimethoxyaniline
To a solution of l-methyl-lH-pyrazole-3-carboxylic acid (1.0 g, 7.93 mmol), 2,6- dimethoxyaniline (1.34 g, 8.72 mmol) and DMAP (48.4 mg, 0.40 mmol, 0.05 equiv) in DCM/DMF (20 mL/4 mL) was added EDCI (1.82 g, 9.52 mmol). The mixture was stirred at room temperature overnight. The mixture was then diluted with DCM (40 mL) and washed with LhO (20 mL). The water phase was extracted with DCM (2* 40 mL). The combined organic phase was washed with HC1 (lmol/L, 20mL) and brine, dried over anhydrous Na2S04 and filtered through silica gel. The filtrate was concentrated in vacuo to afford the title compound as a brown solid. NMR (DMSO-de) d : 8.68 (s, 1H), 7.80 (d, J = 2.4 Hz, 1H), 7.22 (t, J = 8.4 Hz, 1H), 6.69 (d, J = 8.4 Hz, 2H), 6.67 (d, J = 2.4 Hz, 1H), 3.93 (s, 3H), 3.72 (s, 6H). LC-MS: m/z 262.1 (M+H)+
The synthetic route of 2734-70-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANNAPURNA BIO INC.; TANG, Haifeng; BOYCE, Sarah; HANSON, Michael; NIE, Zhe; (213 pag.)WO2019/169193; (2019); A1;,
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