Synthesis and antitumor activity of A-ring modified hexacyclic analogs of camptothecin was written by Li, Dizao;Wang, Cunying;Pan, Xiandao;Liu, Hongyan;Fu, Zhaodi;Wu, Song. And the article was included in Yaoxue Xuebao in 2005.Name: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
The biol. activity of A-ring modified analogs of camptothecin was improved. A-ring modified camptothecins were synthesized from 10-hydroxycamptothecin or 7-ethyl-10-hydroxycamptothecin (SN-38) in 3 or 4 steps. Their cytotoxicity was evaluated using MTT assay, and their in-vivo antitumor activity against mouse liver cancer H22 was tested. Five hexacyclic camptothecins are target compounds, and ten camptothecin derivatives are new compounds The modification of an 1,4-oxazin-2-one ring-fused with positions 9 and 10 of A-ring will reduce the antitumor activity of camptothecins. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Name: 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem