Application of 41365-75-7, A common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-bromo-4-chloro-2-(methylsulfanyl)pyrimidine (9.2 g, 38.4 mmol), K2003 (6.9 g, 49.9 mmol) and 3,3-diethoxypropan-1-amine (5.65 g, 38.4 mmol) were added to DMF (80 mL). The reaction was stirred for 3 h then quenched with H20 (100 mL), extracted with diethyl ether(2 x 75 mL) and dried over MgSO4. After filtration the filtrate was concentrated under reduced pressure to afford 5-bromo-N-(3,3-diethoxypropyl)-2-(methylsulfanyl)pyrimidin-4-amine 11 a (13.2 g, 98%) as a yellow gum. LC-MS (Method A) 351.9 [M+H] RT 3.32 mm.
The synthetic route of 41365-75-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REDX PHARMA PLC; COOPER, Ian; LYONS, Amanda; (102 pag.)WO2017/137743; (2017); A1;,
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