Adding a certain compound to certain chemical reactions, such as: 1535-73-5, name is 3-Trifluoromethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1535-73-5, Product Details of 1535-73-5
General procedure: A mixture of B (1 mmol) and dichloromethane (10 ml) was stirred for 10 min, then EDCI (1.2 mmol) and HOBt (1.2 mmol) were added. Added the appropriate amine (1.2 mmol) into the mixed solution after 30 min and refluxed for 12 h. The reaction mixture was filtrated with water and then the filtrate was dried and evaporated. Purification by silica gel afforded C1-C27
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Trifluoromethoxyaniline, and friends who are interested can also refer to it.
Reference:
Article; Ni, Hai-Jun; Cheng, Hui-Jie; Ge, Wei-Wei; Lin, Meng-Xue; Li, Qing-Shan; Ruan, Ban-Feng; Letters in drug design and discovery; vol. 13; 6; (2016); p. 495 – 504;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem