Arabinogalactan propargyl ethers: Au-catalysed hydroamination by imidazols was written by Grishchenko, Lyudmila A.;Parshina, Lidiya N.;Larina, Lyudmila I.;Belovezhets, Lyudmila A.;Klimenkov, Igor V.;Ustinov, Alexander Yu.;Trofimov, Boris A.. And the article was included in Carbohydrate Polymers in 2020.HPLC of Formula: 111-77-3 This article mentions the following:
A method for synthesis of pharmacol. prospective arabinogalactan (AG) imidazole- and benzimidazole derivatives in a yield of up to 97% via Au(III)-catalyzed hydroamination of AG propargyl ethers has been developed. It is found that in the presence of 5 mol% HAuC14 and 10-fold excess imidazole relative to the propargyl groups, the hydroamination successfully competes with crosslinking processes to afford products soluble in DMSO and aqueous HCl solutions (degree of substitution of imidazolylpropenyl fragments 0.5-1.8, yield 62-97%). It is established that under the conditions of hydroamination Au(III) is reduced to give mainly Au(0) and minor amounts of Au(I), which are contained in AG imidazole derivatives as particles of 190-640 nm in size. Hydrochlorides of Au-containing AG imidazole derivatives show high bacteriostatic activity with respect to test gram-pos. microorganisms and thus confirming their prospects as new AG-derived bioactive agents. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3HPLC of Formula: 111-77-3).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 111-77-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem