N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols was written by Shibuya, Masatoshi;Orihashi, Takayuki;Li, Yamei;Yamamoto, Yoshihiko. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:
N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp3)-H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate were developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent played a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alc. was also demonstrated. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem