Shier, W. Thomas published the artcileInhibition of acyl coenzyme A:lysolecithin acyltransferases by local anesthetics, detergents and inhibitors of cyclic nucleotide phosphodiesterases, HPLC of Formula: 637-58-1, the publication is Biochemical and Biophysical Research Communications (1977), 75(1), 186-93, database is CAplus and MEDLINE.
Acyl coenzyme A:lysolecithin acyltransferase [9027-64-9] activity in microsomal preparations from rat liver, rat heart, and rabbit gastric mucosa was inhibited by a series of tertiary amine local anesthetics, detergents, and some inhibitors of cyclic nucleotide phosphodiesterases. Aspirin [50-78-2] and indomethacin [53-86-1] cause elevated lysolecithin/lecithin ratios in the stomachs of mice after oral administration. Inhibition of acyltransferase activity in microsomal preparations by local anesthetics correlated with reported anesthetic potencies at approx. 1/100 reported therapeutic dosages. In BHK-13 cells acyltransferase activity was inhibited at 1/3 to 1/10 the concentrations that have been reported to cause alterations in the mobility and topog. of cell surface receptors.
Biochemical and Biophysical Research Communications published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C14H10O4S2, HPLC of Formula: 637-58-1.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem