Zhang, Huixia published the artcileDiscovery, SAR, and putative mode of action of N-benzyl-2-methoxybenzamides as potential bleaching herbicides, Application In Synthesis of 6850-57-3, the publication is Pest Management Science (2021), 77(6), 2804-2811, database is CAplus and MEDLINE.
Herbicides acting on biosynthesis of plant pigments have contributed greatly to weed control in recent years. In our previous studies, 2-methoxybenzamides were discovered as a novel type of lead compound for the development of bleaching herbicides. A total of 67 benzamide analogs were synthesized and evaluated for herbicidal activity. The structure-activity relationship (SAR) revealed that a methoxyl substitution at the 2-position of the benzoyl moiety is essential for the herbicidal activity of benzamide derivatives, and introduction of small substituents at the meta- or para-position of the benzylamine moiety is also beneficial. Compounds 4, 43 and 44 showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at an application rate of 150 g a.i. ha-1. The relationship between the structure and herbicidal activity of 2-methoxybenzamides was discussed intensively. Compounds 4, 43 and 44 may serve as novel candidates with a bleaching effect.
Pest Management Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H12ClNO, Application In Synthesis of 6850-57-3.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem