Yokoyama, Naokata's team published research in Journal of Medicinal Chemistry in 38

Yokoyama, Naokata published the artcileSynthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine, Quality Control of 2944-47-0, the publication is Journal of Medicinal Chemistry (1995), 38(4), 695-707, database is CAplus and MEDLINE.

Aryloxamic acids I (R = NHCOCO₂H, R¹ = Br, Me) and II, (arylamino)acetic acids I (R = NHCHRCO₂H, R¹ = Cl, Me, iodo, R² = Gly-OH, Ala-OH, Phe-OH), arylpropionic acids I (R = CH₂CH₂CO₂H, R¹ = Br, Me), arylthioacetic acids I (R = SCH₂CO₂H, R¹ = Br, Me), and (aryloxy)acetic acid I (R = OCH₂CO₂H, R¹ = Br), related to L-triiodothyronine (L-T₃) were prepared and tested in vitro for binding to the rat liver nuclear L-T₃ receptor and the rat membrane L-T₃ receptor. The structure-activity relationships for the prepared compounds are described, with several I and II showing excellent potency to the nuclear receptor and significantly lower binding affinity to the membrane receptor (IC₅₀ > 5 μM). Some of these compounds, especially in the oxamic acid series I (R = NHCOCO₂H) and II, showed an unprecedented potency for methyl-substituted derivatives such as I (R = NHCOCO₂H, R¹ = Me) and (±)-II. I (R = NHCOCO₂H, R¹ = Me) and (±)-II showed good lipid lowering effects in rats with ED₅₀ = 20 and 5 μg/kg po, resp., and a lack of cardiac side effects in rats at doses as high as 10 and 25 mg/kg po, resp.

Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H12O2, Quality Control of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem