Bates, Roderick W. published the artcileTetrahydropyran synthesis by intramolecular conjugate addition to enones: synthesis of the clavosolide tetrahydropyran ring, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Synthesis (2010), 2935-2942, database is CAplus.
The synthesis of a tetrahydropyran intermediate for clavosolide A is reported, employing a combination of cross-metathesis and intramol. oxa-Michael addition The intramol. oxa-Michael addition to α,β-unsaturated esters requires the use of strong bases and can result in either modest yields or stereo-isomeric mixtures, and can be highly variable according to the substrate structure. In contrast, the corresponding ketones cyclize under very mild conditions to give the 2,6-cis-isomers directly. The use of appropriately substituted ketones allows efficient conversion into esters.
Synthesis published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem