Vellakkaran, Mari published the artcileAn Efficient and Selective Nickel-Catalyzed Direct N-Alkylation of Anilines with Alcohols, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is ACS Catalysis (2017), 7(12), 8152-8158, database is CAplus.
Herein, we developed an efficient and selective nickel-catalyzed monoalkylation of various primary alcs. with aryl and heteroaryl amines together with diols and amino alc. derivatives Notably, the catalytic protocol consisting of an earth-abundant and non-precious NiBr2/L1 (L1 = 1,10-phenanthroline) system enables the transformations in the presence of hydroxyl, alkene, nitrile, and nitro functionalities. As a highlight, we have demonstrated the alkylation of diamine, intramol. cyclization to N-heterocycles, and functionalization of complex vitamin E, an (±)-α-tocopherol derivative Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate-determining step.
ACS Catalysis published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C18H35NO, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem