Kunzek, Herbert published the artcileSelectively S-protected cysteine peptides. IV. Synthesis of cysteine peptides using the S-ethylthio protecting group. II, Formula: C2H8Cl2N4S2, the publication is Journal fuer Praktische Chemie (Leipzig) (1980), 322(2), 186-98, database is CAplus.
S-Guanylthiocysteine was treated with RSH (R = Et, Me2CH) to give H-Cys(SR)-OH, which were treated with R1F [R1 = p-PhC6H4CMe2O2C (Bpoc), PhCMe2O2C (Ppoc)] to give R1-Cys(R)-OH (R = Et, R1 = Bpoc, Ppoc; R = CHMe2, R1 = Ppoc). Bpoc-Cys(SEt)-OH and Ppoc-Cys(SEt)-OH were used in the conventional solution synthesis of H-Val-Cys(SEt)-Ala-Leu-OCMe3, which was coupled to BOC-Cys(SEt)-Cys(Dpm)-Ala-Gly-OH (BOC = Me3CO2C, Dpm = CHPh2) by dicyclohexylcarbodiimide/N-hydroxybenzotriazole to give BOC-Cys(SEt)-Cys(Dpm)Ala-Gly-Val-Cys(SEt)-Ala-Leu-OCM3 (I). In the above synthesis, the EtS group was stable in all steps, including deprotection of Bpoc and Ppoc group. I was EtS-deblocked by HSCH2CH2OH to give BOC-Cys-Cys(Dpm)-Ala-Gly-Val-Cys-Ala-Leu-OCMe3, which was oxidized to give protected insulin A 6-13 analog II.
Journal fuer Praktische Chemie (Leipzig) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem