Craviso, Gale L. published the artcileCompetitive inhibition of stereospecific opiate binding by local anesthetics in mouse brain, HPLC of Formula: 637-58-1, the publication is Life Sciences (1975), 16(12), 1803-8, database is CAplus and MEDLINE.
Cationic local anesthetics inhibited competitively the stereospecific binding of naltrexone (I) [16590-41-3] and etorphine [14521-96-1] to the mouse brain opiate receptor. In contrast, the inhibition produced by benzocaine [94-09-7], a noncationic local anesthetic, was noncompetitive. Thus, it appears that the cationic group of local anesthetics interacts with a specific anionic binding site on the opiate receptor and that there are certain structural similarities between the receptors for both types of drugs. In addition, several drugs appear to be able to unspecifically modify the pharmacol. effects of opiates and they could be useful tools to further characterize the opiate receptor.
Life Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, HPLC of Formula: 637-58-1.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem