Jayaraman, Arumugam published the artcilePractical and scalable synthesis of borylated heterocycles using bench-stable precursors of metal-free lewis pair catalysts, Formula: C11H17BO3S, the publication is Organic Process Research & Development (2018), 22(11), 1489-1499, database is CAplus.
Five-membered heterocycles undergo borylation and hydroboration with HBpin boronate in a green scalable process under catalysis with o-phenylene borate-amine frustrated Lewis pairs, yielding substituted boronic esters. A practical and scalable metal-free catalytic method for the borylation and borylative dearomatization (hydroboration) of pyrroles and indoles has been developed. This synthetic method uses inexpensive and conveniently synthesizable bench-stable precatalysts of the form 1-NHR2-2-BF3-C6H4, com. and synthetically accessible heteroarenes as substrates, and pinacolborane as the borylation reagent. The preparation of several borylated heterocycles on 2 and 50 g scales was achieved under solvent-free conditions without the use of Schlenk techniques or a glovebox. A kilogram-scale borylation of one of the heteroarene substrates was also achieved using this cost-effective green methodol. to exemplify the fact that our methodol. can be conveniently implemented in fine chem. industries.
Organic Process Research & Development published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Formula: C11H17BO3S.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem