Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 768-70-7, name is 3-Ethynylanisole, This compound has unique chemical properties. The synthetic route is as follows., name: 3-Ethynylanisole
General procedure: To a stirred solution of alkyne (12mmol, 1.2equiv) in 50mL DCM was added copper(I)-thiophene-2-carboxylate (CuTc, 95mg, 0.5mmol, 0.05equiv). The solution was cooled to 0C and treated dropwise with a solution of 10mmol sulfonyl azide in 10mL DCM. Then, the reaction mixture was stirred a further 12h, monitored by TLC. After reaction, it was diluted with 30mL saturated NH4Cl and extracted with DCM (30mL¡Á3). The combined organics were washed with brine, dried with Na2SO4 and concentrated in vacuo. The crude product was then purified by flash chromatography (Petroleum ether/EtOAc=5:1-1:1). Subsequent recrystallization from EtOAc/Petroleum ether provided the title triazoles substrates.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 768-70-7.
Reference:
Article; Meng, Jiang; Ding, Xiangfeng; Yu, Xingxin; Deng, Wei-Ping; Tetrahedron; vol. 72; 1; (2016); p. 176 – 183;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem