Cid, Jose Maria published the artcileDiscovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor, HPLC of Formula: 622-86-6, the main research area is metabotropic glutamate mGluR2 PAM modulator allosteric; pyridone derivative SAR preparation; PAM; allosteric; glutamate; mGluR2; metabotropic; modulators.
A series of 1,5-disubstituted pyridones was identified as pos. allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several compounds with improved in vitro activity. Lead compound 8 (I) was further profiled and found to attenuate the increase in PCP induced locomotor activity in mice.
ACS Chemical Neuroscience published new progress about Allosterism. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, HPLC of Formula: 622-86-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem