Wang, Shixue published the artcileSynthesis of Y-Shaped OEGylated Poly(amino acid)s: The Impact of OEG Architecture, Computed Properties of 23783-42-8, the main research area is PEGylation polyamino acid glutamic structure.
OEGylation is an attractive approach to modifying poly(amino acid)s. OEG conjugation improves water-solubility of poly(amino acid)s, and confers possible thermal-responsive functionality for the conjugated poly(amino acid)s. Nevertheless, the impact of OEG architecture and the manner in which the OEG moiety interferes with the performances of poly(amino acid)s remain a work in progress. In this study, a series of new linear and Y-shaped OEG-substituted poly(glutamic acid)s were designed and synthesized. It is found that the thermoresponsive behavior of OEGylated poly(glutamic acid)s experiences steric repulsion effect, the strengths of which are architecture and length-dependent, and grows pronounced only when the number of the OEG units is ≥6. Notably, the Y-shaped architecture is able to stabilize the helicity of poly(glutamic acid) backbones, while maintaining higher α-helical conformation than its linear counterparts. In sum, our result indicate that Y-shaped architecture is more appropriate toward OEGylating poly(amino acid)s for biomedical applications.
Biomacromolecules published new progress about Conformation. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Computed Properties of 23783-42-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem