Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,6-Difluoro-3,5-dimethoxyaniline
a) 5-[2,6-Difluoro-3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-ylamine A mixture of 4-Amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (2.45 g, 14.5 mmol), 2,6-difluoro-3,5-dimethoxyaniline (2.75 g, 14.5 mmol), and camphorsulfonic acid (1.01 g, 4.35 mmol) in toluene (80 ML) was heated at reflux for 18 hours (note: the flask was equipped with a Dean-Stark trap).The solvent was removed under reduced pressure to afford a yellow solid.The crude product was sufficiently pure, so it was taken on to the next step.To a suspension of the crude imine (~4.93 g) in tetrahydrofuran (60 ML) at 0 C., lithium aluminum hydride (820 mg, 21.6 mmol) was added in several portions.Caution, gas evolution! The resulting yellow suspension was then stirred at 0C. for 1 hour, whereupon a green solution was afforded.water (1 ML), 15% aqueous sodium hydroxide (1 ML), and water (3 ML) were added sequentially.Care is advised during this quenching protocol.The resulting mixture was then stirred at 0 C. for 10 minutes.The suspension was then filtered over a pad of Celite, and the Celite was rinsed with dichloromethane.The combined filtrates were concentrated under reduced to give a thick oil.Recrystallization was accomplished with a solvent mixture of dichloro-methane:hexanes:methanol (17:8.5:1, 312 ML) to give 1.85 g of the desired aniline.The mother liquor was concentrated and recrystallized with the same solvent mixture to give an additional 0.48 g of product.The second mother liquor was concentrated and recrystallized to afford 0.84 g.The precipitates were combined to give 3.17 g (64%, for 2 steps) of the title compound: MS (APCI) 343.1, 344.1.
According to the analysis of related databases, 651734-54-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chivikas Connolly, Cleo J.; Deur, Christopher James; Hamby, James Marino; Hoyer, Denton Wade; Limberakis, Chris; Reed, Jessica Elizabeth; Schroeder, Mel Conrad; Taylor, Clarke; US2004/19210; (2004); A1;,
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