Kakiuchi, Ryo published the artcileA 19F-MRI probe for the detection of Fe(II) ions in an aqueous system, Formula: C9H20O5, the main research area is MRI probe detection iron.
Iron deposits are often observed in the brains of patients with neurodegenerative diseases, including Alzheimer′s and Parkinson′s diseases. This study outlines the development of F-Nox-1 (I) as the first example of a 19F-MRI probe that can selectively detect Fe(II) in aqueous solutions The use of tetrafluoro-p-phenylenediamine (TFPDA) as a 19F signal emitter with an Fe(II)-selective chem. switch, based on our previously reported N-oxide chem., yielded a readout of a symmetry-dependent 19F signal change in response to Fe(II). The addition of Fe(II) ions to F-Nox-1 triggered a 19F signal change, both in the chem. shift and signal intensity, and the response was highly selective to Fe(II) over other biol. relevant metal ions. The probe could also detect Fe(II) in serum containing various biol. contaminants by 19F magnetic resonance imaging (19F-MRI). Imaging of soluble Fe(II) species, which is the major component of water-soluble iron species, by 19F-MRI will potentially enable the direct monitoring of the elevation of Fe(II) levels prior to the formation of iron deposits, which is a potential risk factor for neurodegenerative diseases.
Organic & Biomolecular Chemistry published new progress about Blood analysis. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Formula: C9H20O5.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem