Aranapakam, Venkatesan published the artcileSynthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis, Category: ethers-buliding-blocks, the main research area is arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity.
A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported.
Journal of Medicinal Chemistry published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem