Kawashima, Yutaka published the artcileStructure-activity studies of 3-benzoylpropionic acid derivatives suppressing adjuvant arthritis, Application In Synthesis of 622-86-6, the main research area is antiarthritic benzoylpropionate.
3-Benzoylpropionic acid derivatives possess an immunomodulative activity and suppress adjuvant arthritis. To understand how substituents affect the biol. activity, the quant. structure-activity relationships of 30 compounds were analyzed by the adaptive least-squares method. For the suppressing activity in rats, the electronic effects and the structural feature of the substituent on benzene ring were suggested to be important. To reinforce and confirm the correlation, 4 addnl. compounds of phenoxybutyric acid derivatives were synthesized and tested with the rat adjuvant-induced arthritis. These compounds were found to have potent suppressing activity.
Chemical & Pharmaceutical Bulletin published new progress about Antiarthritics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem