Bury, Ross W. published the artcileInteractions between local anesthetics and spasmogens on the guinea-pig ileum, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Journal of Pharmacology and Experimental Therapeutics (1976), 197(3), 633-40, database is CAplus and MEDLINE.
The effect of various local anesthetics and other substances known to modify Ca fluxes in cells, on submax. responses of guinea pig ileum to substance P [33507-63-0], acetylcholine, histamine, and BaCl2 was determined Procaine-HCl [51-05-8] caused a dose-related depression of the response to all the agonists but the response to substance P was far less susceptible to this depression. Lidocaine-HCl [73-78-9], bupivacaine-HCl [18010-40-7], pramoxine-HCl [637-58-1] and W 6211 [22759-46-2] also caused a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine, and BaCl2. Verapamil [52-53-9] caused a dose-related depression of responses to all the agonists equally. The use of Ca-free solutions abolished responses to substance P, acetylcholine, and histamine. The response to BaCl2 was less affected by Ca withdrawal but was reduced markedly. In the presence of 10 mM LaCl, the response to all the agonists was abolished. The relative resistance of the substance P responses to antagonism by local anesthetics suggests that different and more efficient channels for Ca entry into the smooth muscle cell are involved.
Journal of Pharmacology and Experimental Therapeutics published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.
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https://en.wikipedia.org/wiki/Ether,
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