Frisell, Wilhelm R. published the artcileThe binding sites of sarcosine oxidase, Safety of 2-Methoxyacetamide, the publication is Journal of Biological Chemistry (1955), 275-85, database is CAplus.
cf. C.A. 48, 7680h. Methoxyacetate and acetate inhibit the oxidative demethylation of sarcosine by liver mitochondria competitively and to a comyarative degree. When the carboxylate group of either inhibitor is replaced by a less polar substituent, the order of inhibitory activity is COO– > CHO â?CH2OH > CONH2. Substitution in the terminal Me group decreased the inhibition in the order: Me > CH2F > CH2Cl > CH2Br > CH2I. In the methoxyacetate series, binding is proportional to the nucleophilic character of the β-position: N > O > S > CH2. It is deduced that the carboxylate group is bound to the active surface by an NH4, guanidinium, or other electrophilic substituent, and that the Me group is bound by a hydrocarbon moiety. In addition to these primary sites there is a 3rd site, electrophilic in nature, which binds N, O, or S. From the comparable activity of methoxyacetate and acetate it is deduced that the carboxylate- and Me-binding sites comprise contiguous corners of a square pattern in which the O, N, and S binding site is a 3rd corner. In fitting such a surface, methoxyacetate and sarcosine assume their most compact or square configuration. MeOCH2CO2Et with concentrated NH4OH yielded the amide, m. 97-9° (uncorrected). HSCH2CO2Et treated with MeI in alc. NaOMe and the product hydrolyzed with NaOH yielded S-methylthioglycolic acid, b20 119-20°.
Journal of Biological Chemistry published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Safety of 2-Methoxyacetamide.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem