Hu, Liqun published the artcileAn Intermolecular Hydroarylation of Highly Deactivated Styrenes Catalyzed by Re2O7/HReO4 in Hexafluoroisopropanol, Synthetic Route of 91-16-7, the publication is ACS Catalysis (2022), 12(10), 5857-5863, database is CAplus.
Here, authors describe an activation mode for unactivated alkenes on the basis of a synergy between Re2O7/HReO4 and hexafluoroisopropanol (HFIP). Highly electron-deficient styrenes have been activated to effect a challenging intermol. hydroarylation with different arenes to give a variety of diarylalkanes in high efficiency. This method is characterized by mild reaction condition, broad substrate scope, high chem. yields, and minimal waste generation. The potential synthetic application of this methodol. was exemplified by the efficient synthesis of a retinoic acid receptor (RAR) agonist. DFT calculations and deuterium-labeling experiments were conducted to elucidate the reaction mechanism, and both confirmed the critical role of HFIP, which significantly reduced the energetical barriers for several key steps of this transformation via a network of hydrogen bonding to perrhenate anion with two equivalent of HFIP.
ACS Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 91-16-7.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem