McBride, Christopher M.’s team published research in Journal of Medicinal Chemistry in 57 | CAS: 596819-12-4

Journal of Medicinal Chemistry published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Application In Synthesis of 596819-12-4.

McBride, Christopher M. published the artcileDesign, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990, Application In Synthesis of 596819-12-4, the publication is Journal of Medicinal Chemistry (2014), 57(21), 9124-9129, database is CAplus and MEDLINE.

Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/pharmacodynamic relation in vivo was developed from a com. hit. The exploration of this series led to the selection of NVP-HSP990 as a development candidate.

Journal of Medicinal Chemistry published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C11H17BO3S, Application In Synthesis of 596819-12-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem