Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.
Hickey, Deirdre M. B. published the artcileSynthesis of thyroid hormone analogs. Part 3. Iodonium salt approaches to SK & F L-94901, Application of 2-Isopropylanisole, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1988), 3103-11, database is CAplus.
The key step in the synthesis of the title compound L–I, a novel, selective, and potent thyromimetic, is the formation of the hindered diaryl ether moiety. This paper describes an investigation into the formation of the required diaryl ether by copper-catalyzed reaction both of sym. iodonium salts, e.g. R2I+ O2CCF3, and mixed iodonium salts II (R1 = H, R2 = OMe; R1 = R2 = H, OMe) with protected dibromotyrosine 4,3,5-HO(Br)2C6H2CH2CH(NHCOCF3)CO2Me. The importance of the counterion of the iodonium salt is discussed. This work is extended to a large-scale synthesis of SK & F L-94901 (I).
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem