Bridoux, Alexandre published the artcileDesign, synthesis, and biological evaluation of bifunctional thyrointegrin inhibitors: new anti-angiogenesis analogs, Computed Properties of 2944-47-0, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2011), 26(6), 871-882, database is CAplus and MEDLINE.
Context: Inhibition of pathol. angiogenesis. Objective: Obtaining new transactivator, bifunctional, thyroid antagonist, non-toxic anti-angiogenic compounds Materials and methods: In silico drug design, synthesis in bulk and biol. evaluation in chick chorioallantoic membrane (CAM) model. Results: Significant inhibition (range 65-73%) at 0.25-2.0 μg/mL doses. Discussion and conclusion: The synthesis of compounds (9), (10), and (11) incorporating long-chain moieties guanidine, urea, Me amine and, Pr amine substitutions, resp., into the core mol. framework of tetrac (tetraiodothyroacetic acid) were undertaken. The evaluation of the anti-angiogenic bioactivity of these compounds in the CAM model revealed no loss of activity in comparison with tetrac and XT199, which showed nearly 86% inhibition at dose levels of 1 and 0.5 μg/mL, resp., and validated the concept.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Computed Properties of 2944-47-0.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem