Thoma, K. published the artcileColloid association and bioavailability of local anesthetics. Part 7. Partition behavior, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Pharmaceutica Acta Helvetiae (1988), 63(6), 155-9, database is CAplus and MEDLINE.
The partition coefficient was determined for 20 local anesthetics and was found to be considerably influenced by the chem. structure and the substituents present in the compounds In the system n-octanol/buffer (pH 5.7) partition coefficients between 0.05 (brufacaine-HCl) and 199.0 (chinisocaine-HCl) were found. In the system n-octanol/water they ranged between 0.003 (procaine-HCl and lidocaine-HCl) and 4.2 (oxetacaine-HCl). Raising the pH-value from 4 to 6 resulted in an increase of the partition coefficient of stadacain-HCl from 8.9 to 56.5. Raising the ionic strength from 0.2 to 1.0 of a pH 5.7 buffer increased the partition coefficient of stadacain-HCl from 30.4 to 95.3%. The addition of 5.0% NaCl to an aqueous, unbuffered solution of stadacain-HCl increased the partition coefficient from 0.36 to 27.2.
Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C5H5BrN2, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem