Thoma, K. published the artcileColloid association and bioavailability of local anesthetics. Part 6. Mixed micelle formation with polysorbates, Product Details of C17H28ClNO3, the publication is Pharmaceutica Acta Helvetiae (1988), 63(4-5), 102-10, database is CAplus and MEDLINE.
For 19 surface-active local anesthetics, the binding to polyethylene glycol sorbitan fatty acid esters (I) by formation of mixed micelles was determined All surface-active local anesthetics investigated, except procaine-HCl and lidocaine-HCl, form mixed micelles with I. In the presence of 5% I in water, this binding fluctuates between 5.3% for butacaine sulfate and 75% for cyclomethycaine-sulfate. For all local anesthetics the quotient of the total concentration and the free moiety is proportional to the surfactant concentration The surfactant bound moiety of the local anesthetic is constant when it is below its critical micellar concentration (CMC). Above the CMC, deviations from this rule are observed The binding of tetracaine-HCl to I by mixed micelles formation demonstrates that the binding to these surfactants increases with the shortened fatty acid chain (that means an increasing HLB-value). When the pH-value or ionic strength increases, stadacain-HCl exhibits a distinct increase of the binding by a change of the dissociation-rate or a salting-out effect. Changing the solvent of stadacain-HCl from water to saline, for example, increases the binding to 5% I from 38.1 to 68%.
Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C19H14N2, Product Details of C17H28ClNO3.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem