Hikawa, Hidemasa published the artcileA borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water, Formula: C13H14N2O, the publication is Green Chemistry (2018), 20(13), 3044-3049, database is CAplus.
A greener borrowing hydrogen methodol. using the π-benzylpalladium system, which offered an efficient and environmentally friendly preparation of N-benzyl aminopyridines I [R1 = H, 5-F, 3-Me, etc.; R2 = H, 3-Me, 4-t-BuO, etc.; R3 = H, Me] via dehydrative N-monobenzylation of 2-aminopyridines with benzylic alcs. in the absence of base was demonstrated. The crossover experiment using benzyl-α,α-d2 alc. and 3-methylbenzyl alc. afforded H/D scrambled products, suggesting that the dehydrative N-benzylation in the catalytic system involved a borrowing hydrogen pathway. KIE experiments showed that C-H bond cleavage at the benzylic position of benzyl alc. was involved in the rate-determining step (KIE = 2.9). This simple base-free protocol could be achieved under mild conditions in an atom-economic process, affording the desired products in moderate to excellent yields.
Green Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem