Chang, Hson Mou published the artcileCompounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen), Related Products of ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (1991), 34(5), 1675-92, database is CAplus and MEDLINE.
Twenty-one o-quinonoid-type compounds, e.g. I–VI and one coumarin-type compound related to miltirone (VII) were synthesized for identification of the key structural elements involved in the reaction of VII with the central benzodiazepine receptor. Based on their inhibition of [3H]flunitrazepam binding to bovine cerebral cortex membranes, it was apparent that ring A of VII is essential for affinity. Although increasing the size of ring A from 6-membered to 7- and 8-membered is well-tolerated, the introduction of polar hydroxyl groups greatly reduces binding affinity. The presence of 1,1-di-Me groups on ring A is, however, not essential, but the iso-Pr group on ring C appears to be critical for binding as its removal decreases affinity by more than 30-fold. Its replacement with an Me group causes only a minimal reduction in affinity. Linking ring A and B with an -CH2CH2– bridge results in analog VIII which is 6 times more potent than VII at the central benzodiazepine receptor (IC50 = 0.05 μM).
Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem