Barrulas, Pedro published the artcileSynthesis of novel cinchona-amino acid hybrid organocatalysts for asymmetric catalysis, Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Tetrahedron: Asymmetry (2014), 25(12), 923-935, database is CAplus.
Three novel subclasses of cinchonidine derivatives coupled to diverse amino acids were prepared in very good overall yield and tested in a benchmark organocatalytic aldol reaction, between acetone and aromatic aldehydes. These subclasses are a family of amino acid-cinchonidine (subclass A), N-formamides-cinchonidine (subclass B) and dipeptide-cinchonidine (subclass C) hybrids. The main goal, besides obtaining very good yield and enantioselectivity was to understand the influence of the amino acid side chain residues on the enantioselectivity of the asym. aldol reactions. Different amino acid tethered cinchonidine hybrids were compared and their catalytic behavior was evaluated, allowing good enantioselectivity to be achieved, 92% ee in one case. Other reactions such as Biginelli, Michael addition and ketimine hydrosilylation reactions were screened with these ligands, but the outcome was less successful. The synthesis of the target compounds (organocatalysts) was achieved by a reaction of (8α,9S)-cinchonan-9-amine [epi-(amino)cinchonidine] with amino acids, such as N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
Tetrahedron: Asymmetry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem