Duriatti, Albert published the artcileIn vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules, SDS of cas: 622-86-6, the main research area is oxidosqualene sterol cyclase intermediate analog inhibitor; plant oxidosqualene sterol cyclase inhibitor; liver oxidosqualene sterol cyclase inhibitor.
2-Aza-2,3-dihydrosqualene and related mols., a series of new compounds designed as analogs of the transient carbocationic high-energy intermediate occurring in the oxirane ring opening during cyclization of 2,3-oxidosqualene, were tested in vitro as inhibitors of the microsomal 2,3-oxidosqualene cyclase of animals (rat liver) and of higher plants (maize, pea). These mols. proved to be good and specific inhibitors for the cyclases of both phyla. The inhibition is due to pos. charged species and is sensitive to steric hindrance around the N atom. 4,4,10β-Trimethyl-trans-decal-3β-ol and 4,10β-dimethyl-trans-decal-3β-ol, which have previously been described (J. A. Nelson et al., 1978) as inhibitors of the 2,3-oxidosqualene cyclase of CHO cells, were noncompetitive inhibitors of the rat liver microsomal enzyme and presented no activity towards the higher plants cyclases. Aza derivatives of these decalines, which were aimed to mimic the C-8 carbocationic intermediate occurring during later steps of the 2,3-oxidosqualene cyclization did not inhibit the cyclases. This result underlines the theor. limitations of the high-energy analog concept in designing enzyme inhibitors. Among mols. tested, 2,3-epiminosqualene was a reversible, noncompetitive inhibitor of the cyclases; similarly U18666A was a very potent inhibitor of the microsomal cyclases. In contrast, AMO 1618, a known anticholesterolemic agent reported previously to act at the level of the 2,3-oxidosqualene cyclization step, did not appear to act directly on the cyclases.
Biochemical Pharmacology published new progress about Corn. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem