70627-52-0, Adding a certain compound to certain chemical reactions, such as: 70627-52-0, name is N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 70627-52-0.
Example 10 Process for the Preparation of 3-[5-Benzyloxy-2-[(4-benzyloxy-phenyl)-(4-fluoro-phenylamino)-methyl]-5-(4-fluoro-phenyl)-pentanoyl]-4-phenyl-oxazolidin-2-one 18 ml of Dichloromethane was added to 2.1 ml of TiCl4 at 20-25 C. under nitrogen atmosphere Cooled the reaction mass to 0 C., 2 ml of Ti(O-ipr)4 was added and stirred for about 15 minutes. To the reaction mass 50 ml Dichloromethane, 10 gms of 1-[5-Benzyloxy-5-(4-fluoro-phenyl)-pentanoyl]-5-phenyl-pyrrolidin-2-one and 13.7 gms of Imines were added at 20-25 C. under nitrogen atmosphere. The reaction mass was cooled -30to -35 C. and 5.8 gms of Diisopropyl ethyl amine was added. Stirred the reaction mass for about 15 minutes and TiCl4 solution was added. Stirred the reaction mass for about 2-3 hours at -30to -35 C. and 60 ml of isopropyl alcohol was added followed by 50 ml of Dichloromethane and stirred the reaction mass for about 60 minutes, 6% Tartaric acid solution was added to the reaction mass at 20-25 C. and stirred for about 2 hours. Separate the organic layer and extract the reaction mass with 100 ml of dichloromethane. Combined the organic layers and washed with H2O followed by brine solution. Separated the organic layer and dried over Sodium Sulfate. Distilled the solvent completely under reducing pressure at 50-55 C. and 500 ml of methanol was added. Stirred the reaction mass for about 1-2 hours at 20-25 C., filtered the compound, washed with methanol and dried at 60-65 C. to get 8 gms of 3-[5-Benzyloxy-2-[(4-benzyloxy-phenyl)-(4-fluoro-phenylamino)-methyl]-5-(4-fluoro-phenyl)-pentanoyl]-4-phenyl-oxazolidin-2-one.
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Reference:
Patent; Mylan Laboratories Limited; Husain, Mofazzal; G.S.C., Srikanth; Thorpunuri, Swapna; Datta, Debashish; (11 pag.)US2016/280642; (2016); A1;,
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