Zhao, Qiang published the artcileRadical α-addition involved electrooxidative [3 + 2] annulation of phenols and electron-deficient alkenes, Application In Synthesis of 121-00-6, the main research area is phenol alkene electrooxidative regioselective diastereoselective cycloaddition; aryl dihydrobenzofuran preparation green chem.
An electrooxidative [3 + 2] annulation of phenols and electron-deficient alkenes for the synthesis of C3-functionalized 2-aryl-2,3-dihydrobenzofuran derivatives was achieved. The ring construction started by a unique α-addition of carbon radicals derived from anodic oxidation of phenols to electron-deficient alkenes. The subsequent anodic oxidation of the resulting alkyl radical intermediates followed by trapping with the phenolic hydroxy group assembles the 2,3-dihydrobenzofuran core. Such a pathway enabled the installation of various electrophilic functionalities including alkoxycarbonyl, alkylaminocarbonyl, trifluoromethyl, and cyano groups at the C-3 of the 2,3-dihydrobenzofuran framework, which is unattainable by other intermol. reactions. The application of this method for a rapid synthesis of a bioactive natural product was demonstrated.
Chemical Science published new progress about [3+2] Cycloaddition reaction, stereoselective (electrochem.). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem