Wu, Zhao published the artcileAsymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination, Safety of 2-Methoxy-5-methylphenylboronic acid, the main research area is amine rhodium catalyst tandem chemoselective enantioselective reductive amination.
A general asym. route for the one-pot synthesis of chiral γ-branched amines through the highly enantioselective isomerization of allylamines, followed by enamine exchange and subsequent chemoselective reduction was reported. This protocol was suitable for establishing various tertiary stereocenters, including those containing dialkyl, diaryl, cyclic, trifluoromethyl, difluoromethyl, and silyl substituents, which allowed for a rapid and modular synthesis of many chiral γ-branched amines. To demonstrate the synthetic utility, Terikalant and Tolterodine were synthesized using this method with high levels of enantioselectivity.
Nature Communications published new progress about Amines, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Safety of 2-Methoxy-5-methylphenylboronic acid.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem