Mao, Wuyu published the artcileOrganocatalytic and Scalable Syntheses of Unsymmetrical 1,2,4,5-Tetrazines by Thiol-Containing Promotors, Synthetic Route of 23783-42-8, the main research area is tetrazine derivative preparation; nitrile heterocyclization olefination; annulations; heterocycles; nitriles; organocatalysis; synthetic methods.
Despite the growing application of tetrazine bioorthogonal chem., it is still challenging to access tetrazines conveniently from easily available materials. Described here is the de novo formation of tetrazine from nitriles and hydrazine hydrate using a broad array of thiol-containing catalysts, including peptides. Using this facile methodol., the syntheses of 14 unsym. tetrazines, containing a range of reactive functional groups, on the gram scale were achieved with satisfactory yields. Using tetrazine methylphosphonate as a building block, a highly efficient Horner-Wadsworth-Emmons reaction was developed for further derivatization under mild reaction conditions. Tetrazine probes with diverse functions can be scalably produced in yields of 87-93 %. This methodol. may facilitate the widespread application of tetrazine bioorthogonal chem.
Angewandte Chemie, International Edition published new progress about Heterocyclization. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Synthetic Route of 23783-42-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem