Design, synthesis and anti-TNBC activity of Azeliragon triazole analogues was written by Xie, Jizhao;Xu, Huanji;Wu, Xinduo;Xie, Yunfeng;Lu, Xiuhong;Wang, Lisheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:
Triple-neg. breast cancer (TNBC) is the most aggressive subtype of breast cancer. Many studies have shown a significant increase in the marker signal of the receptor for advanced glycation end-products (RAGE) with the malignant progression of tumor growth, metastasis and recurrence of breast cancer, including TNBC of primary tumors and lymph node metastases. Azeliragon is a RAGE inhibitor and it has been shown to actively inhibit the TNBC cell line, SUM149 (IC50 = 5.292 ± 0.310 μM). In order to develop a new anti-TNBC agent, we designed, synthesized and screened 26 Azeliragon triazole analogs to determine their anti-TNBC activities in vitro. The most active compound was KC-10 (3-(4-(5-butyl-1-(4′-chloro-[1,1′-biphenyl]-4-yl)-1H-1,2,4-triazol-3-yl)phenoxy)-N, N-diethylpropan-1-amine) with an IC50 value of 0.220 ± 0.034 μM. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2-Methoxyethylamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem