Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes was written by Yuan, Zhenbo;Zeng, Yuye;Feng, Ziwen;Guan, Zhe;Lin, Aijun;Yao, Hequan. And the article was included in Nature Communications in 2020.Application of 103-16-2 The following contents are mentioned in the article:
A palladium-catalyzed asym. tandem Heck/carbonylation desymmetrization of cyclopentenes I (R = COMe, CO2Et; R1 = H, F, Cl, Me, OMe; X = I, Br) has been described. Alcs., (such as., n-propanol, isopropanol, cyclohexanol, etc.) phenols (such as., 4-methylphenol, biphenyl-4-ol, naphthol, etc.) and amines (such as., pyrrolidine, morpholine, benzylamine, etc.) are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes II (R2 = OMe, OEt, OPh, pyrrolidino, morpholino, thiomorpholino, etc.) with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asym. tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 103-16-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem