Reference of 24332-20-5,Some common heterocyclic compound, 24332-20-5, name is 1,1,2-Trimethoxyethane, molecular formula is C5H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 1,1,-2-trimethoxyethane (2.07 [ML,] 16.07 [MMOL)] in 0.5M HCI (32 mL) was heated at [100C] for 2 h. The cooled mixture was extracted with [CH2C12] (30 mL) and the organic solution dried (3A molecular sieves). 3-Bromo-2-methylphenylamine was added and the resultant solution stirred under nitrogen for 20 min. Acetic acid (461 [UL,] 8.05 [MMOL)] and sodium triacetoxyborohydride (4.78g, 22.56 [MMOL)] were added and the reaction mixture stirred under nitrogen at room temperature for 16 h. Saturated sodium bicarbonate (60 mL) was added portionwise and the resultant mixture stirred for 0.5 h and extracted with CH2CI2 (2 x 100 mL). The organic solution was dried [(NA2SO4)] and the solvents removed in vacuo. Purification by SPE (silica, 2 x 20g) eluted with 100: 2 to 100: 5 cyclohexane : EtOAc afforded the title compound as a yellow oil (687mg). LC/MS: [M/Z] 246 [M+H] +, Rt 3.27 min.
The synthetic route of 24332-20-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/762; (2003); A2;,
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Ether | (C2H5)2O – PubChem