Hsu, Jessie Hao-Ru et al. published their research in Cell Chemical Biology in 2020 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: 4-Benzyloxyphenol

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex was written by Hsu, Jessie Hao-Ru;Rasmusson, Timothy;Robinson, James;Pachl, Fiona;Read, Jon;Kawatkar, Sameer;O’ Donovan, Daniel H.;Bagal, Sharan;Code, Erin;Rawlins, Philip;Argyrou, Argyrides;Tomlinson, Ronald;Gao, Ning;Zhu, Xiahui;Chiarparin, Elisabetta;Jacques, Kelly;Shen, Minhui;Woods, Haley;Bednarski, Emma;Wilson, David M.;Drew, Lisa;Castaldi, M. Paola;Fawell, Stephen;Bloecher, Andrew. And the article was included in Cell Chemical Biology in 2020.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

Deregulation of the PRC2 complex, comprised of the core subunits EZH2, SUZ12, and EED, drives aberrant hypermethylation of H3K27 and tumorigenicity of many cancers. Although inhibitors of EZH2 have shown promising clin. activity, preclin. data suggest that resistance can be acquired through secondary mutations in EZH2 that abrogate drug target engagement. To address these limitations, we have designed several hetero-bifunctional PROTACs (proteolysis-targeting chimera) to efficiently target EED for elimination. Our PROTACs bind to EED (pKD ~9.0) and promote ternary complex formation with the E3 ubiquitin ligase. The PROTACs potently inhibit PRC2 enzyme activity (pIC50 ~8.1) and induce rapid degradation of not only EED but also EZH2 and SUZ12 within the PRC2 complex. Furthermore, the PROTACs selectively inhibit proliferation of PRC2-dependent cancer cells (half maximal growth inhibition [GI50] = 49-58 nM). In summary, our data demonstrate a therapeutic modality to target PRC2-dependent cancer through a PROTAC-mediated degradation mechanism. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem