Synthetic Route of 111-95-5, The chemical industry reduces the impact on the environment during synthesis 111-95-5, name is Bis(2-methoxyethyl)amine, I believe this compound will play a more active role in future production and life.
To a stirred solution of DCM, bis(2-methoxyethyl)ami?e (40.0 g, 44.0 ml_, 300 mmol), and triethylamine (69.25 ml_, 500 mmol), under a nitrogen atmosphere at -78 0C was added drop wise bromo acetyl bromide (34.8 ml_, 400 mmol). After stirring at -78 0C for 5 h, the reaction mixture was allowed to warm up to -20 0C and then quenched by addition of water (60 ml_). The organic phase was washed with distilled water (3 x 30 ml_), saturated ammonium chloride (3 x 30 ml_), saturated sodium bicarbonate (3 x 30 ml_) and brine (2 x 30 ml_). The organic phase was then dried over magnesium sulfate, filtered and solvents removed via rotary evaporation to yield a crude product in 82 % yield (62.3 g, 245 mmol). The crude product was then distilled under high vacuum at 170 C to give pale yellow crystals in 49 % yield (35.57 g, 140 mmol). Pure product can also be recrystallised from the crude material with diethyl ether.1H delta ppm 4.02 (s, 2H), 3.66 (t, J = 5.2 Hz, 2H), 3.55 (br, 3H), 3.53 (t, J = 5.0 Hz, 3H), 3.33 (s, 6H)13C delta ppm 167.79, 70.74, 70.27, 59.13, 58.94, 50.12, 46.90, 27.20
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bis(2-methoxyethyl)amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DUBLIN CITY UNIVERSITY; WO2009/24607; (2009); A1;,
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