Biotransformation of pungent constituents from ginger (Zingiber officinale Roscoe) by Colletotrichum gloeosporioides yields oxidative ortho-ortho coupling products was written by de Avila, Roberta Marques Dias;Toffano, Leonardo;Fernandes, Joao Batista;da Silva, Maria Fatima das Gracas Fernandes;de Sousa, Lorena Ramos Freitas;Vieira, Paulo Cezar. And the article was included in Biocatalysis and Biotransformation in 2022.SDS of cas: 2380-78-1 The following contents are mentioned in the article:
This work investigated the biotransformation of ginger constituents (zingerone, [6]-shogaol, [6]-gingerol, and methyl-[6]-gingerol) by the pathogenic fungus Colletotrichum gloeosporioides. Experiments were carried out with and without deuterium-labeled compounds The product metabolites were analyzed by liquid chromatog. coupled to tandem mass spectrometry and liquid chromatog. solid phase extraction-NMR. Substrates supplied to the fungus were incorporated into metabolic pathways mostly by oxidation reactions, including aromatic carbon-carbon coupling. Zingerone and [6]-gingerol biotransformation products included biphenol dimers. A biodegradation pathway for biphenol formation was proposed based on the presence of the intermediate 4-(2-hydroxyethyl)-2-methoxyphenol, commonly identified from [6]-gingerol and [6]-shogaol biodegradation This intermediate likely originates from a Baeyer-Villiger reaction followed by hydrolysis. The C-C coupling of mols. could result in phenolic oxidative ortho-ortho coupling, suggesting that biphenol dimers are products of C. gloeosporioides laccase catalysis. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1SDS of cas: 2380-78-1).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 2380-78-1
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